Gulf War Illness Research Studies

Gulf War Illness Research Studies

The following is a list of Gulf War Illness research studies:

1.  White, R. F., et al., Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effects of toxicant exposures during deployment. Cortex (2015). Abstract conclusion: We conclude that exposure to pesticides and/or to PB are causally associated with GWI and the neurological dysfunction in GW veterans. Exposure to sarin and cyclosarin and to oil well fire emissions are also associated with neurologically based health effects, though their contribution to development of the disorder known as GWI is less clear. Gene-environment interactions are likely to have contributed to development of GWI in deployed veterans. The health consequences of chemical exposures in the GW and other conflicts have been called “toxic wounds” by veterans. This type of injury requires further study and concentrated treatment research efforts that may also benefit other occupational groups with similar exposure-related illnesses.

2.  Iowa Persian Gulf Study Group. Self-reported illness and health status among Gulf War veterans: A population-based study. Journal of the American Medical Association 1997;277:238–45. Abstract conclusion: Assessed (1) the prevalence (PV) of self-reported symptoms and illnesses among Iowa military personnel deployed during the Persian Gulf War (PGW) and compared the PV of these conditions with that among Ss on active duty at the same time, but not deployed to the Persian Gulf (non-PGW); and (2) the relationship between self-reported medical and psychiatric conditions (MPCs) and the type of military service. 4,886 Ss were classified into 1 of 4 study domains: PGW regular military, PGW National Guard/Reserve, non-PGW regular military, and non-PGW National Guard/Reserve; overall, 3,695 Ss completed a cross-sectional telephone interview survey designed to assess MPCs. Results showed that Ss who participated in the PGW have a higher self-reported PV of MPCs than Ss who were not deployed to the Persian Gulf. Also, larger differences in PV between PGW and non-PGW Ss were observed in the National Guard/Reserve comparison. (PsycINFO Database Record (c) 2012 APA, all rights reserved)

3.  Eisen SA, Kang HK, Murphy FM, et al. Gulf War Study Participating Investigators. Gulf War veterans' health: medical evaluation of a U.S. cohort. Ann Intern Med. 2005 Jun 7;142(11):881-90. Abstract conclusion: In summary, 10 years after the 1991 Gulf War, the physical health of deployed veterans is similar to that of nondeployed veterans. However, deployment is associated with an increased risk for fibromyalgia, the chronic fatigue syndrome, certain skin disorders, and dyspepsia. Health care providers should be particularly alert for these conditions when examining veterans who served in the Persian Gulf region during either the 1991 Gulf War or the current conflict. More field studies are needed, perhaps with prospective monitoring of U.S. personnel deployed in the Middle East for the development of these conditions. Continued research, particularly directed at elucidating mechanisms for these associations, is warranted.

4.  Odegard, T. N., Cooper, C. M., Farris, E. A., Arduengo, J., Bartlett, J., & Haley, R. (2013). Memory impairment exhibited by veterans with Gulf War illness. Neurocase, 19(4), 316e327. Abstract conclusion: Roughly 26–32% of US veterans, who served in the first Gulf War, report suffering from chronic health problems (Golomb, 2008, Proceedings of the National Academies of Science, 105, 4295). The present study investigated the memory deficits reported by these ill Gulf War veterans (GWV) using a face–name associative memory paradigm administered during functional magnetic resonance imaging (fMRI). The fMRI data confirmed memory performance on the memory task to be related to the amount of activation in the left hippocampus observed during the study. In addition, ill-GWV demonstrated decreased memory performance relative to unaffected GWV on this memory test, providing evidence of memory deficits using an objective measure of memory.

5.  Golomb, B. A., & Golomb, B. (2012). Oxidative stress and mitochondrial injury in chronic multisymptom conditions: From Gulf War illness to autism spectrum disorder. Nature Precedings. Abstract conclusion: GWI is compatible with a paradigm by which uncompensated exposure to oxidative/nitrative stressors accompanies and triggers mitochondrial dysfunction, cell energy compromise, and multiple downstream effects such as vulnerability to autoantibodies. This promotes a profile of protean symptoms with variable latency emphasizing but not confined to energy-demanding post-mitotic tissues, according with (and accounting for) known properties of multisystem overlap conditions. This advances understanding of GWI; health conditions attending GWI at elevated rates; and overlap conditions like CFS and ASD, providing prospects for vulnerability assessment, mitigation of progression, treatment, and future prevention – with implications germane to additive and excessive environmental oxidative stressor exposures in the civilian setting.

6.  Koslik, H. J., Hamilton, G., & Golomb, B. A. (2014). Mitochondrial dysfunction in Gulf War illness revealed by 31Phosphorus Magnetic Resonance Spectroscopy: a case-control study. PloS one, 9(3), e92887. Abstract conclusion: These data provide the first direct evidence supporting mitochondrial dysfunction in Gulf War illness. Findings merit replication in a larger study and/or corroboration with additional mitochondrial assessment tools.

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