What is Fibromyalgia?
Fibromyalgia (FM) is a nervous system disorder characterized by widespread musculoskeletal pain often accompanied by other multisystem symptoms. It is believed that people with fibromyalgia experience amplified pain signals due to an abnormality in the way the brain processes pain signals. In some cases, symptoms gradually accumulate over time however in other cases, symptoms are precipitated by a triggering event such as physical trauma, infection, or a significant psychological stress event.
It is estimated that up to 5 million Americans currently have fibromyalgia with the vast majority of affected individuals being women.
Symptoms of fibromyalgia may include:
- Generalized body pain
- Significant fatigue
- Tension headaches
- Cognitive impairment
- Unrefreshing sleep
- Irritable bowel syndrome
How is Fibromyalgia Linked to Mitochondrial Dysfunction?
Recent studies have shown evidence demonstrating that oxidative stress may play a role in the pathophysiology of FM. Signs and symptoms associated with muscular alteration and mitochondrial dysfunction have been reported in patients with fibromyalgia .